Mirta Dumancic, Ph.D.
Passion for Discovery and Clinical Impact
microdosimetry, radiobiological modeling, DNA damage & repair, alpha radiotherapy, particle physics, empowering in STEM
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microdosimetry, radiobiological modeling, DNA damage & repair, alpha radiotherapy, particle physics, empowering in STEM
I am a medical physics researcher whose career bridges fundamental physics and translational cancer research. From studying particle physics at CERN to developing patient-specific radiobiological models at McGill University, I carry my passion for research into every aspect of my academic work. Currently, my work explores how the physics of radiation can advance personalized cancer therapy. Having worked and lived across Europe, Israel, and Canada, I’ve experienced both the challenges and the excitement of international scientific collaboration. I am passionate about mentoring and empowering women in STEM—helping them lead with integrity, confidence, and joy as they pursue meaningful careers in science. Both in research and teaching, I believe in moving forward with vision and purpose.
Recent Publications
Microdosimetry Model for Clinically Relevant Photon Sources
In this study, we link precise microdosimetry calculations with early DNA damage measurements across clinical photon energies. We show a clear relationship between the microdosimetric energy density of the radiation quality and biological response in human cancer cells.
Intrinsic Radiosensitivity Markers
We compared sub-lethal damage repair kinetics derived from clonogenic survival assays with molecular DNA repair across four human cancer cell lines. We found that while the survival-based half-time of repair correlated with intrinsic radiosensitivity, the molecular foci clearance did not reliably predict that sensitivity.
Diffusing Alpha-Emitters Radiation Therapy in vivo
In this study, we investigated how alpha-emitting sources spread and act within different tumor types to optimize a new form of targeted radiation therapy called Alpha-DaRT. The findings revealed consistent diffusion patterns that help guide the treatment planning in new clinical trials.
ICRP TG116 Publication
In this multicenter international study, we assessed the dose from CBCT imaging with various protocols and linac machines. We suggest a protocol that can be used to enable most radiotherapy centres across the world to engage in meaningful imaging dose measurement and optimisation.
Women in Radiation Physics
We reviewed the stories of pioneering women in nuclear and radiation sciences, tracing their breakthroughs from the discovery of radioactivity through the mid-20th century. Recognising these women’s contributions not only honours scientific history but also provides vital role models for future generations of women in STEM.
Z-boson production in Pb+Pb collisions at CERN
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“Nothing in life is to be feared; it is only to be understood.
Now is the time to understand more, so that we may fear less.”
- Marie Curie.
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